Interstate 44 (I-44) is a major Interstate Highway in the central United States. Its western terminus is in Wichita Falls, Texas at a concurrency with U.S. Route 277 (US 277), US 281, and U.S. Route 287 in Texas; its eastern terminus is at I-70 in St. Louis, Missouri. I-44 is one of five interstates built to bypass U.S. Route 66; this highway covers the section between Oklahoma City and St. Louis.

Virtually the entire length of I-44 east of Springfield, Missouri was once US 66, which was upgraded from two to four lanes from 1949 to 1955. The section of I-44 west of Springfield was built farther south than US 66 in order to connect Missouri's section with the already completed Will Rogers Turnpike, which Oklahoma wished to carry their part of I-44.

Major intersections

Texas

US 82 / US 277 / US 281 / US 287 in Wichita Falls (western terminus)

US 287 in Wichita Falls

Oklahoma

I‑240 in Oklahoma City

I‑40 in Oklahoma City

I‑235 in Oklahoma City

I‑35 in Oklahoma City

I‑244 in Tulsa

Missouri

US 166 / US 400 near Joplin

I-49 / US 71 near Joplin

US 160 in Springfield

US 65 in Springfield

US 63 in Rolla

US 50 near Union

I-270 in Sunset Hills

US 50 / US 61 / US 67 in Kirkwood

I-55 / I-64 / US 40 in St. Louis

I-70 in St. Louis (eastern terminus)

Auxiliary routes

• Tulsa, Oklahoma - I-244, I-444 (unsigned)
• St. Louis, Missouri - I-244 decommissioned in 1974, today signed as I-270.