Major intersections

California

I‑405 in West Los Angeles

I‑110 southwest of Downtown Los Angeles

I‑5 at the East Los Angeles Interchange in Los Angeles

I‑710 in East Los Angeles

I‑605 in El Monte/Baldwin Park

I‑15 in Ontario

I‑215 south of Downtown in San Bernardino

I‑210 in Redlands

Arizona

I‑17 in Phoenix (twice)

I‑8 in Casa Grande

I‑19 in Tucson

New Mexico

I‑25 in Las Cruces

Texas

US 54 / I-110 in El Paso (Locals refer to this junction as the "Spaghetti Bowl")

I-20 near Kent

I-410 in San Antonio (twice: Northwest and Eastside)

I-35 and I-37 in Downtown San Antonio

I-45 in Houston

I-69 in Houston

I-610 in Houston (twice, Westside and Eastside)

Louisiana

I‑210 in Lake Charles

I‑49 in Lafayette

I‑110 and I‑12 in Baton Rouge

I‑55 in Laplace

I‑310 near Kenner

I‑610 (twice), Future I‑49, and I‑510 in New Orleans

I‑12 and I‑59 in Slidell

Mississippi

I-110 in Biloxi

Alabama

I‑65 in Mobile

Florida

I‑110 in Pensacola

I‑75 in Lake City

I‑295 at the western beltway interchange in Jacksonville

I‑95 in Downtown Jacksonville

Auxiliary routes

• Los Angeles, California: I-110, I-210, I-710
• San Bernardino, California: I-210
• El Paso, Texas: I-110
• San Antonio, Texas: I-410
• Houston, Texas: I-610
• Lake Charles, Louisiana: I-210
• Baton Rouge, Louisiana: I-110
• New Orleans, Louisiana: I-310, I-510, I-610, I-910
• Biloxi, Mississippi: I-110
• Pensacola, Florida: I-110